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KMID : 0361020000430040416
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Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 4 p.416 ~ p.420
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Autogenous Mucosa-Lined Tracheal Prosthesis
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Baek Chung-Hwan
Lee Jong-Chan
Shin Jun-Ho
Chu Kwang-Chol
Kim Ho-Joong
Suh Soo-Won
Kim Jhin-Gook
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Abstract
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Background and Objectives : Reliable prosthetic or tissue graft of trachea for reconstruction of large,
circumferential tracheal defect has not yet been developed. The major limitations in this area have been
anastomotic dehiscence and stenosis, which are attributed to poor epithelialization and vascularization of
prosthetic grafts.
Materials and Method : We developed a new tracheal prosthesis which has a viable lined mucosa and is
well-vascularized. The prosthesis consists of Prolene mesh reinforced with polypropylene rings, and is
coated with gelatin. We lined the luminal surface of the prosthesis with transplanted autogenous oral
mucosa and wrapped the prosthesis with greater omentum. Animal experiments were performed using 8
adult Mongrel dogs.
Results : The transplanted mucosa and the greater omentum that was wrapped were tightly adhered to
the prosthesis to make a single unit within two weeks. The mucosa survived well, having been
vascularized by new vessels from the greater omentum, and showed normal histology.
Conclusion : We concluded that this highly biocompatible tracheal prosthesis could be very useful for
staged reconstruction of tracheal defects.
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KEYWORD
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Tracheal prosthesis, Prolene mesh, Autologous mucosa transplantation, Omental wrapping
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